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Registros recuperados: 3
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Isolated ileal interposition in enteroendocrine L cells differentiation Nature Precedings
Bianca Marigliani; Joao-Luiz M. C. Azevedo; Lucas P. F. F. Leal; Ismael D. C. G. Silva; Valderez B. V. Lapchick; Sang W. Han; Karina F. Neves; Linda O. A. Bernardes; Gilmara S. A. Yamaguchi; Wellington Cardia; Jose F. Borborema; Joao L. C. Azevedo; Otavio C. Azevedo; Gustavo P. S. Miguel.
INTRODUCTION: 
Due to the progressive nature of type 2 diabetes, its complexity and drug treatment perpetuity, there is currently a search for surgical procedures that can promote euglycemia also in non-obese patients. Diabetic patients glycemic control can be achieved by increasing the blood concentration of GLP-1, a hormone produced by L cells that are more densely concentrated in the terminal ileum. Early and extended improvement of diabetes in patients submitted to bariatric surgeries awakened the necessity of investigating the isolated ileal interposition as surgical alternative for the treatment of diabetes. The interposition of this ileal segment to a more anterior region (proximal jejunum) can promote a greater stimulation of the L...
Tipo: Manuscript Palavras-chave: Molecular Cell Biology.
Ano: 2011 URL: http://precedings.nature.com/documents/6614/version/2
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Isolated ileal interposition in enteroendocrine L cells differentiation Nature Precedings
Bianca Marigliani; Joao-Luiz M. C. Azevedo; Lucas P. F. F. Leal; Karina F. Neves; Linda O. A. Bernardes; Gilmara S. Aguiar-Yamaguchi; Wellington Cardia; João L. C. Azevedo; Otavio C. Azevedo; Jose F. Borborema; Gustavo P. S. Miguel.
INTRODUCTION: 
Due to the progressive nature of type 2 diabetes, its complexity and drug treatment perpetuity, there is currently a search for surgical procedures that can promote euglycemia also in non-obese patients. Diabetic patients glycemic control can be achieved by increasing the blood concentration of GLP-1, a hormone produced by L cells that are more densely concentrated in the terminal ileum. Early and extended improvement of diabetes in patients submitted to bariatric surgeries awakened the necessity of investigating the isolated ileal interposition as a surgical alternative for the treatment of diabetes. The interposition of this ileal segment to a more anterior region (proximal jejunum) can promote a greater stimulation of the...
Tipo: Manuscript Palavras-chave: Molecular Cell Biology.
Ano: 2011 URL: http://precedings.nature.com/documents/6614/version/1
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Imprime registro no formato completo
Structural changes in intestinal enteroendocrine cells after ileal interposition in normal rats Nature Precedings
Gilmara S. Aguiar-Yamaguchi; João-Luiz M. C. Azevedo; Marcelo C. Carlini; Paolo H. B. Lourenco; Wellington Cardia; Maria T. S. Alves; Aparecida E. Hirata; Lucas P. F. F. Leal; Bianca Marigliani; Linda O. A. Bernardes; Karina F. Neves; Rudy N. Rocha; José-Francisco Borborema; João-Luiz C. Azevedo; Otavio C. Azevedo; Gustavo P. S. Miguel.
INTRODUCTION: No therapeutic approach has significantly impacted the progression of diabetes. As early improvement of glicaemic control is observed after bariatric surgeries, there is currently a search for surgical procedures that can promote euglycemia also in non-obese patients. Glicaemic control can be achieved by increasing the blood concentration of GLP-1, a hormone produced by L cells that are more densely concentrated in the terminal ileum. The interposition of ileal segment to a more anterior region (proximal jejunum) can promote a greater stimulation of the L cells by poorly digested food, increasing the production of GLP-1 and reflecting on glicaemic control.
AIMS: To investigate long-term histological modifications of...
Tipo: Manuscript Palavras-chave: Developmental Biology; Molecular Cell Biology.
Ano: 2011 URL: http://precedings.nature.com/documents/6683/version/1
Registros recuperados: 3
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