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| Santos,Olímpia Maria Martins; Reis,Maria Esther Dias; Jacon,Jennifer Tavares; Lino,Mônica Esselin de Sousa; Simões,Juliana Savioli; Doriguetto,Antonio Carlos. |
| Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polymorphism; Medicines/quality control; Medicines/solubility; Medicines/bioavailability. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100002 |
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