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| Li,Xiping; Gao,Ping; Zhang,Chengliang; Wu,Tao; Xu,Yanjiao; Liu,Dong. |
| Mung bean seed coat (MBSC) is a healthcare product in Asian countries. The aim of this study was to investigate the effect of an MBSC ethanol extract on the bioavailability of cyclosporine A (CsA) in rats. Rats were orally dosed with CsA alone or in combination with MBSC ethanol extracts (500 mg/kg, p.o.). The blood levels of CsA were assayed by liquid chromatography with an electrospray ionization source and tandem mass spectrometry (LC-MS/MS). The everted rat intestinal sac technique was used to determine the influence of MBSC on the absorption of CsA. The results reveal that combined CsA intake with MBSC decreased the Cmax, AUC0-t, t1/2z and MRT0-t values of CsA by 24.96%, 47.28%, 34.73% and 23.58%, respectively (P<0.05), and significantly raised the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mung bean/seed coat/health care use; Mung bean/seed coat/ethanolic extract/properties; Cyclosporine A/bioavailability. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300591 |
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| Wu,Tao; Wu,Ji; Gao,Ping; Xiang,Daochun; Liu,Dong; Song,Hongping. |
| abstract The aim of this study was to evaluate the effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites. Rats were intragastrically administered caffeine (30 mg·kg-1, once per day), tea polyphenol (400 mg·kg-1, once per day) or daidzein (13.5 mg·kg-1, once per day) for 14 days, followed by an intragastric administration of lansoprazole (8 mg·kg-1) on the 15th day. The plasma concentrations of lansoprazole and its two primary metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Tea polyphenol significantly elevated the Area Under the Curve (AUC) of lansoprazole from 680.29 ± 285.99 to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lansoprazole/pharmacokinetics; Caffeine/effects/lansoprazole pharmacokinetics; Tea polyphenol/effects/lansoprazole pharmacokinetics; Daidzein/effects/lansoprazole pharmacokinetics; 5-hydroxylansoprazole; Lansoprazole sulfone; Hepatic microsomal enzyme/inhibition.. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400893 |
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