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Protection against neurotoxicity by an autophagic mechanism BJMBR
Liu,Kangyong; Huang,Jiankang; Chen,Rongfu; Zhang,Ting; Shen,Liwei; Yang,Jiajun; Sun,Xiaojiang.
The objective of the present study was to investigate the effects of 3-n-butylphthalide (NBP) on a 1-methyl-4-phenylpyridinium (MPP+)-induced cellular model of Parkinson’s disease (PD) and to illustrate the potential mechanism of autophagy in this process. For this purpose, rat PC12 pheochromocytoma cells were treated with MPP+ (1 mM) for 24 h following pretreatment with NBP (0.1 mM). Cell metabolic viability was determined by the MTT assay and cell ultrastructure was examined by transmission electron microscopy. The intracellular distribution and expression of α-synuclein and microtubule-associated protein light chain 3 (LC3) were detected by immunocytochemistry and Western blotting. Our results demonstrated that: 1) NBP prevented MPP+-induced...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 3-N-butylphthalide; Parkinson’s disease; Α-synuclein; PC12 cells; Autophagy.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500004
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