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	Provedor de dados Biol. Res. (2) Autor Lizama,Carlos (2) Moreno,Ricardo D (2) Lagos-Cabré,Raúl (1) Reyes,Juan G (1) Silva,Doris (1) Tapia,Verónica (1) Urriola-Muñoz,Paulina (1) Mais... Palavra-chave Apoptosis (2) Testis (2) Caspase (1) Metalloproteinase (1) Paracrine (1) Sertoli cell (1) Spermatocyte (1) Spermatogenesis (1) Thyroid (1) Mais... Tipo do documento Journal article (2) Ano 2014 (1) 2011 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation Biol. Res. Urriola-Muñoz,Paulina; Lizama,Carlos; Lagos-Cabré,Raúl; Reyes,Juan G; Moreno,Ricardo D. BACKGROUND: Extracellular metolloproteases have been implied in different process such as cell death, differentiation and migration. Membrane-bound metalloproteases of the ADAM family shed the extracellular domain of many cytokines and receptor controlling auto and para/juxtacrine cell signaling in different tissues. ADAM17 and ADAM10 are two members of this family surface metalloproteases involved in germ cell apoptosis during the first wave of spermatogenesis in the rat, but they have other signaling functions in somatic tissues. RESULTS: In an attempt to further study these two enzymes, we describe the presence and localization in adult male rats. Results showed that both enzymes are detected in germ and Sertoli cells during all the stages of... Tipo: Journal article Palavras-chave: Testis; Spermatogenesis; Apoptosis; Paracrine; Metalloproteinase. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100031 Propylthiouracil-induced hypothyroidism delays apoptosis during the first wave of spermatogenesis Biol. Res. Silva,Doris; Lizama,Carlos; Tapia,Verónica; Moreno,Ricardo D. Mammalian germ cell apoptosis plays a key role in controlling the correct number of germ cells supported by Sertoli cells during the first wave of spermatogenesis in mammalian puberty. However, little is known about hormonal factors that could influence the rate of germ cell apoptosis during puberty or adulthood. In this work we evaluate germ cell apoptosis under hypothyroidism induced by goitrogen propylthiouracil (PTU) during the first wave of spermatogenesis. Neonatally administered PTU promoted a delay in the differentiation of Sertoli cells as evaluated by the expression of clusterin using immunohistochemistry and RT-PCR. Clusterin had different expression levels in control and PTU-treated animals, but under both conditions the highest levels were... Tipo: Journal article Palavras-chave: Testis; Spermatocyte; Sertoli cell; Caspase; Apoptosis; Thyroid. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200010 Registros recuperados: 2 Primeira ... 1 ... Última

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