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| Yu,Liang; Cao,Binbin; Long,Ying; Tukayo,Meks; Feng,Chonglv; Fang,Wenzhen; Luo,Damin. |
| Abstract The mechanisms involved in the fast growth of Angiostrongylus cantonensis from fifth-stage larvae (L5) to female adults and how L5 breaks through the blood-brain barrier in a permissive host remain unclear. In this work, we compared the transcriptomes of these two life stages to identify the main factors involved in the rapid growth and transition to adulthood. RNA samples from the two stages were sequenced and assembled de novo. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of 1,346 differentially expressed genes between L5 and female adults was then undertaken. Based on a combination of analytical results and developmental characteristics, we suggest that A. cantonensis synthesizes a large amount of cuticle in L5 to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Comparative transcriptomes; Cuticle synthesis; Lysine degradation; Lysosomal pathway; Metallopeptidases. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300540 |
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