|
|
|
|
| |
|
|
| Lourenço,Felipe Rebello; Pinto,Terezinha de Jesus Andreoli. |
| Gentamicin is a broad-spectrum antibiotic complex produced by actinomycetes belonging to Micromonospora genus and classified among aminoglycoside antibiotics, used in the treatment of serious infections derived from Gram-negative microorganisms. Alterations of their antimicrobial activity not shown in chemical assays can be evaluated through microbiological assays. The aim of this work was to compare 5 x 1, 2 x 2 and 3 x 1 experimental designs, evaluating validation parameters of specificity, linearity, range, precision, and accuracy for each experimental design in different levels of concentration, presentation, and lots. It consisted of 81 assays (in 3 replicas) of gentamicin microbiological dosage. The concentrations of the solutions used were employed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gentamicin/sulphate; Gentamicin/experimental design; Gentamicin/microbiological dosage; Antibiotics/qualitative analysis; Aminoglycoside antibiotics/antimicrobial activity. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300022 |
| |
|
| |
|
| |
|
| |
|
| |
|
|
| Fukuda,Isa Martins; Pinto,Camila Francini Fidelis; Moreira,Camila dos Santos; Saviano,Alessandro Morais; Lourenço,Felipe Rebello. |
| According to Quality by Design (QbD) concept, quality should be built into product/method during pharmaceutical/analytical development. Usually, there are many input factors that may affect quality of product and methods. Recently, Design of Experiments (DoE) have been widely used to understand the effects of multidimensional and interactions of input factors on the output responses of pharmaceutical products and analytical methods. This paper provides theoretical and practical considerations for implementation of Design of Experiments (DoE) in pharmaceutical and/or analytical Quality by Design (QbD). This review illustrates the principles and applications of the most common screening designs, such as two-level full factorial, fractionate factorial, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Design of Experiments (DoE); Quality by Design (QbD); Factorial Designs; Central Composite Designs (CCD); Box-Behnken Designs; Response Surface Methodology (RSM). |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700405 |
| |
|
|
|
