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	Provedor de dados BJMBR (1) Autor Koch,W. (1) Luna,F. (1) Scior,T. (1) Sánchez-Ruiz,J.F. (1) Palavra-chave E3 ubiquitin-protein ligase (1) Low homology model (1) RING finger structure (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2007 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein BJMBR Scior,T.; Luna,F.; Koch,W.; Sánchez-Ruiz,J.F.. Almost identical polyglutamine-containing proteins with unknown structures have been found in human, mouse and rat genomes (GenBank AJ277365, AF525300, AY879229). We infer that an identical new gene (RING) finger domain of real interest is located in each C-terminal segment. A three-dimensional (3-D) model was generated by remote homology modeling and the functional implications are discussed. The model consists of 65 residues from terminal position 707 to 772 of the human protein with a total length of 796 residues. The 3-D model predicts a ubiquitin-protein ligase (E3) as a binding site for ubiquitin-conjugating enzyme (E2). Both enzymes are part of the ubiquitin pathway to label unwanted proteins for subsequent enzymatic degradation. The molecular... Tipo: Info:eu-repo/semantics/article Palavras-chave: E3 ubiquitin-protein ligase; RING finger structure; Low homology model. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300002 Registros recuperados: 1 Primeira ... 1 ... Última

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