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	Provedor de dados BJMBR (3) Autor Lunardi,C.N. (3) Tedesco,A.C. (2) Bendhack,L.M. (1) Gomes,A.J. (1) Gonzalez,S. (1) Rotta,J.C.G. (1) da Silva,R.S. (1) Mais... Palavra-chave Antioxidant (1) Kojic acid (1) Liposomes (1) Nitric oxide (1) Nitric oxide donor (1) Nitrovasodilator (1) Photodynamic therapy (1) Polypodium leucotomos extract (1) Reactive oxygen species (1) Ruthenium complex (1) S-nitrosothiols (1) Vasodilatation (1) Zinc phthalocyanine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2009 (1) 2003 (1) 2001 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species BJMBR Gomes,A.J.; Lunardi,C.N.; Gonzalez,S.; Tedesco,A.C.. Two natural products Polypodium leucotomos extract (PL) and kojic acid (KA) were tested for their ability to scavenge reactive oxygen species (·OH, ·O2-, H2O2, ¹O2) in phosphate buffer. Hydroxyl radicals were generated by the Fenton reaction, and the rate constants of scavenging were 1.6 x 10(9) M-1 s-1 for KA and 1.0 x 10(9) M-1 s-1 for PL, similar to that of ethanol (1.4 x 10(9) M-1 s-1). With superoxide anions generated by the xanthine/hypoxanthine system, KA and PL (0.2-1.0 mg/ml) inhibited ·O2-dependent reduction of nitroblue tetrazolium by up to 30 and 31%, respectively. In the detection of ¹O2 by rose bengal irradiation, PL at 1.0 mg/ml quenched singlet oxygen by 43% relative to azide and KA by 36%. The present study demonstrates that PL showed an... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polypodium leucotomos extract; Kojic acid; Antioxidant; Reactive oxygen species. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100018 Nitric oxide release from the S-nitrosothiol zinc phthalocyanine complex by flash photolysis BJMBR Rotta,J.C.G.; Lunardi,C.N.; Tedesco,A.C.. The photogeneration of nitric oxide (NO) using laser flash photolysis was investigated for S-nitroso-glutathione (GSNO) and S-nitroso-N-acetylcysteine (NacySNO) at pH 6.4 (PBS/HCl) and 7.4 (PBS). Irradiation of S-nitrosothiol with light (lambda = 355 nm followed by absorption spectroscopy) resulted in the homolytic decomposition of NacySNO and GSNO to generate radicals (GS· and NacyS·) and NO. The release of NO from donor compounds measured with an ISO-Nometer apparatus was larger at pH 7.4 than pH 6.4. NacySNO was also incorporated into dipalmitoyl-phosphatidylcholine liposomes in the presence and absence of zinc phthalocyanine (ZnPC), a well-known photosensitizer useful for photodynamic therapy. Liposomes are usually used as carriers for hydrophobic... Tipo: Info:eu-repo/semantics/article Palavras-chave: S-nitrosothiols; Nitric oxide; Zinc phthalocyanine; Liposomes; Photodynamic therapy. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500005 New nitric oxide donors based on ruthenium complexes BJMBR Lunardi,C.N.; da Silva,R.S.; Bendhack,L.M.. Nitric oxide (NO) donors produce NO-related activity when applied to biological systems. Among its diverse functions, NO has been implicated in vascular smooth muscle relaxation. Despite the great importance of NO in biological systems, its pharmacological and physiological studies have been limited due to its high reactivity and short half-life. In this review we will focus on our recent investigations of nitrosyl ruthenium complexes as NO-delivery agents and their effects on vascular smooth muscle cell relaxation. The high affinity of ruthenium for NO is a marked feature of its chemistry. The main signaling pathway responsible for the vascular relaxation induced by NO involves the activation of soluble guanylyl-cyclase, with subsequent accumulation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide donor; Ruthenium complex; Nitrovasodilator; Vasodilatation. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100013 Registros recuperados: 3 Primeira ... 1 ... Última

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