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| MÜLLER,LUCIELI K.F.; SILVA,ALEKSANDRO S. DA; BOTTARI,NATHIELI B.; SANTURIO,JANIO M.; MORSCH,VERA M.; PIVA,MANOELA M.; MENDES,RICARDO E.; GLORIA,EDUARDO M.; PAIANO,DIOVANI. |
| Abstract: The aim of this study was to evaluate the effect of spray-dried porcine plasma (SDPP) supplementation on cholinesterase enzymes and its relationship with animal behavior of weaning piglets exposed to mycotoxin contaminated diets. To achieve these objectives, two experimental design approaches were used. Male piglets (7.15±0.61kg) were allocated in four groups: CTL group received a regular diet; SDPP group received a regular diet and 6% SDPP; MYC group received a diet containing desired contamination of 210 µg/kg aflatoxins and 6.690 µg/kg fumonisins; group MYC+SDPP received 253 µg/kg aflatoxins, 6930 µg/kg fumonisins and 6% SDPP. The animals treated with mycotoxin co-contaminated diets showed an increase in AChE and BChE activities in peripheral... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mycotoxin; Acetylcholinesterase; Brain; Spray-dried porcine plasma; Animal health. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300807 |
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| BORIN,DIEGO B.; MEZZOMO,NATHANA J.; VAUCHER,RODRIGO A.; CARMO,GUILHERME DO; RODRIGUES JUNIOR,LUIZ C.; SULCZEWSKI,FERNANDO B.; SCHWERTZ,CLAITON I.; MENDES,RICARDO E.; DAMIANI,ADRIANI P.; ANDRADE,VANESSA M. DE; RECH,VIRGÍNIA C.; BOECK,CARINA R.. |
| ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nanoliposomes were produced, characterized and assayed in models of toxicity in vitro and in vivo. Particles showed negative zeta potential (-12,5 mV), polydispersity index 0.237 and medium-size of 105 nm, which was confirmed by transmission electron microscopy (TEM) images. Toxicity assay in vitro was evaluated with blank liposomes (no drug) or creatine nanoliposomes at concentrations of 0.02 and 0.2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanocarrier; Neurodegenerative diseases; Nanotechnology; Liposomes. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502317 |
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| MÜLLER,LUCIELI K.F.; PAIANO,DIOVANI; BOTTARI,NATHIELI B.; SANTURIO,JANIO M.; ZAMPAR,ALINE; SCHETINGER,MARIA R.C.; ZANETTE,RÉGIS A.; MENDES,RICARDO E.; GLORIA,EDUARDO M.; BALDISSERA,MATHEUS D.; SILVA,ALEKSANDRO S. DA. |
| Abstract This study was aimed to analyze the effects of spray-dried porcine plasma (SDPP) on the health of post weaning piglets challenged with diets contaminated with aflatoxins and fumonisins. Fifty-six male piglets (7.15 ± 0.61 kg) were allocated in four groups: CTL group received a regular diet; SDPP group received a regular diet and 6% SDPP; MYC group received a diet containing 300 µg/kg aflatoxins and 8,000 µg/kg fumonisins; group MYC+SDPP received 300 µg/kg aflatoxins, 8,000 µg/kg fumonisins and 6% SDPP. The animals that received the experimental diet containing mycotoxins (MYC group) had lower weight gain at the end of the experiment compared to the other treatments. Animals receiving SDPP showed decreased urea levels throughout the experiment... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Functional foods; Intoxication; Mycotoxins; Pigs; Health. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603115 |
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