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| TAWFEEQ, Mohammad Monir; MIURA, Saori; SUGIMOTO, Kazuya; KOBAYASHI, Yoshiyasu; INOKUMA, Hisashi; 古林, 与志安; 猪熊, 壽. |
| An 8-month-old Holstein heifer with cervical enlargement was suspected of thymic lymphosarcoma given clinical signs of depression, tendency to lie down, cervical mass, jugular vein distension, conjunctival hyperemia, and ruminal tympany. Unilateral Horner’s syndrome was also observed. Increased serum total lactate dehydrogenase (LDH), LDH isozyme (LDH-2, and LDH-3) and serum thymidine kinase activity were observed. The findings of fine needle aspiration cytology of the cervical mass revealed large lymphoblasts with mitoses present. These findings strongly suggested the diagnosis of lymphosarcoma. Necropsy revealed a large mass in the cervical thymic region, which compressed the esophagus and trachea. Cranial masses in the frontal sinus and multiple... |
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Palavras-chave: Brain involvement; Cattle; Thymic lymphosarcoma. |
| Ano: 2012 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4098 |
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| 三浦, 沙織; 千葉, 史織; 高橋, 裕之; 福田, 茂夫; 藤井, 貴志; 新井, 鐘蔵; 古林, 与志安; 猪熊, 壽; MIURA, Saori; CHIBA, Shiori; TAKAHASHI, Hiroyuki; FUKUDA, Shigeo; FUJII, Takashi; ARAI, Shozo; KOBAYASHI, Yoshiyasu; INOKUMA, Hisashi. |
| 38カ月齢のホルスタイン種乳牛において，体全体が左側に傾くという神経症状が進行性に認められた．経過，左側対光反射と左側音響耳介反応の減弱，及び聴性脳幹誘発電位測定検査における左刺激時Ⅲ波-Ⅴ波の遅延所見より，延髄から橋における片側性圧迫性病変を疑った．病理解剖の結果，橋左側に帯黄色脆弱化病巣を認め，病理組織学的検索により，病変は腫瘍であり，迷入組織に由来する可能性があるものの，原発組織は確定できなかった． |
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Palavras-chave: 聴性脳幹誘発電位; 脳幹; 腫瘍; ホルスタイン. |
| Ano: 2014 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4010 |
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| TAWFEEQ, Mohammad Monir; MIURA, Saori; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; 猪熊, 壽. |
| This study evaluated the clinical usefulness of serum thymidine kinase (TK) activity for diagnosing bovine leukosis cases for which clinical diagnosis was difficult (‘BL with difficult diagnosis’). Median TK activity values in 24 ‘BL with difficult diagnosis’ and 36 cattle for which BL was clinically confirmed by cytology findings of enlarged superficial lymph nodes (‘clinically confirmed BL’) were 36.8 and 39.4 U/l, respectively (no significant difference). The percentage with positive TK activity (>5.4 U/l) was also similar in both groups (83.3% for ‘BL with difficult diagnosis’ and 97.2% for ‘clinically confirmed BL’). TK activity was significantly higher in cows with ‘BL with difficult diagnosis’ compared to those with other tumors (N=13) and those... |
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Palavras-chave: Atypical bovine leukosis; Diagnosis; Thymidine kinase. |
| Ano: 2013 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3869 |
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| TAWFEEQ, Mohammad Monir; MIURA, Saori; NAKANISHI, Yuuki; SUGIMOTO, Kazuya; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 古林, 与志安; 猪熊, 壽. |
| A 12-month-old Holstein heifer with anorexia, lameness, and enlargement of peripheral lymph nodes was suspected of having bovine leukosis. Although lymphocytosis was not observed, cytology of fine needle aspirate from a superficial cervical node, and increased serum lactate dehydrogenase and thymidine kinase activities, strongly suggested lymphosarcoma. Increased numbers of mononuclear cells as well as mitotic cells were observed in synovial fluid collected from swollen joints. Pathological examination confirmed B-cell calf form bovine leukosis and joint swelling related to neoplastic cell infiltration. Both interleukin-2 receptor and thymidine kinase 1 genes were highly expressed in cells from superficial cervical lymph node aspirate. |
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Palavras-chave: Calf form bovine leukosis; Gene expression; Joint infiltration. |
| Ano: 2012 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4097 |
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