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| Smith, T. G.; Ellison, J. A.; Carson, W. C.; Ma, X.; Rupprecht, C.. |
| Vaccine potency testing is necessary to evaluate the immunogenicity of inactivated rabies virus (RABV) vaccine preparations before human or veterinary application. Currently, the NIH test is recommended by the WHO expert committee to evaluate intra- and inter-lot variation of RABV vaccines; however, numerous disadvantages are inherent concerning cost, number of animals and biosafety requirements. As such, numerous in vitro methods (e.g. antigen-capture ELISA) have been proposed for the evaluation of vaccines based on RABV glycoprotein (G) quality and quantity which correlates with vaccine potency. In this study an antigen-capture electrochemiluminescent (ECL) assay was developed utilizing three murine anti-RABV G monoclonal antibodies (mAb) to quantify... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/3154 |
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