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	Provedor de dados Genet. Mol. Biol. (1) Autor Flores-Soto,Mario (1) González-Castañeda,Rocío E. (1) Macías-Islas,Miguel A. (1) Ortiz,Genaro G. (1) Sánchez-González,Víctor J. (1) Vázquez-Camacho,Gonzalo (1) Mais... Palavra-chave Alzheimer's disease (1) Brain (1) Choline acetyltransferase (1) Neural restrictive silencer factor (1) Protein expression (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: a pilot study Genet. Mol. Biol. González-Castañeda,Rocío E.; Sánchez-González,Víctor J.; Flores-Soto,Mario; Vázquez-Camacho,Gonzalo; Macías-Islas,Miguel A.; Ortiz,Genaro G.. Decreased Choline Acetyltransferase (ChAT) brain level is one of the main biochemical disorders in Alzheimer's Disease (AD). In rodents, recent data show that the CHAT gene can be regulated by a neural restrictive silencer factor (NRSF). The aim of the present work was to evaluate the gene and protein expression of CHAT and NRSF in frontal, temporal, entorhinal and parietal cortices of AD patient brains. Four brains from patients with AD and four brains from subjects without dementia were studied. Cerebral tissues were obtained and processed by the guanidine isothiocyanate method for RNA extraction. CHAT and NRSF gene and protein expression were determined by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting. CHAT gene... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neural restrictive silencer factor; Choline acetyltransferase; Alzheimer's disease; Protein expression; Brain. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100005 Registros recuperados: 1 Primeira ... 1 ... Última

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