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| Oliveira,Luís Flávio Souza de; Fuentefria,Alexandre Meneghello; Klein,Fernanda da Silva; Machado,Michel Mansur. |
| In the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L.) against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Euphorbia tirucalli L.; Aveloz; Antifungal; Cryptococcus neoformans. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400027 |
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| Güez,Camila Martins; Souza,Raul Oliveira de; Fischer,Paula; Leão,Maria Fernanda de Moura; Duarte,Jonathaline Apollo; Boligon,Aline Augusti; Athayde,Margareth Linde; Zuravski,Luísa; Oliveira,Luís Flávio Souza de; Machado,Michel Mansur. |
| ABSTRACT Ocimum is one of the most important genera of the Lamiaceae family. Several studies about basil and its popular use reveal many characteristics of the herb, including its use as antioxidant, anti-aging, anti-inflammatory, anti-carcinogenic, anti-microbial, and cardiovascular agents, among others. In this paper, we evaluated genotoxic, oxidative, and anti-inflammatory parameters from the extract of Ocimum basilicum in different concentrations, using human leukocytes cultures exposed to challenging agents. Our results confirm that the O. basilicum extract acts as an antioxidant and effectively reverts or subjugates the effects of high oxidizing agents such as hydrogen peroxide. These actions are attributed to its composition, which is rich in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ocimum basilicum/evaluation; Ocimum basilicum/genotoxic effects; Ocimum basilicum/anti-inflammatory properties; Medicinal plants/study.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100606 |
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| Cordeiro,Everson Willian Fialho; Hilgert,Renata Medeiros; Batista,Luiz Alcides das Chagas; Souza,Raul Oliveira; Oliveira,Luís Flávio Souza de; Machado,Michel Mansur; Malesuik,Marcelo Donadel; Paula,Fávero Reisdorfer; Stopiglia,Cheila Denise Ottonelli; Paim,Clésio Soldateli. |
| Danofloxacin is a veterinary fluoroquinolone used to treat respiratory and gastrointestinal diseases of birds, pigs and cattle. The literature reviewed shows some analytical methods to quantify this fluoroquinolone, but microbiological and biological safety studies are limited. The analytical methods were validated by the Official Codes. The LC-DAD method was developed and validated using an RP-18 column, mobile phase containing a mixture of 0.3% triethylamine (pH 3.0) and acetonitrile (85:15, v/v). The microbiological assay was performed by agar diffusion method (3 x 3) and Staphylococcus epidermidis as a microorganism test. Forced degradation studies were performed in both methods. The minimum inhibitory concentration (MIC) was performed by test... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Danofloxacin; Microbiological assay; Biological safety; In silico toxicology; Fluoroquinolones photodegradation. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100555 |
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| Malheiros,Camila Krüger Cardoso; Silva,Joyce Sayonara Barbosa; Hofmann,Tânia Cristiane; Messina,Thiane Martins; Manfredini,Vanusa; Piccoli,Jacqueline da Costa Escobar; Faoro,Débora; Oliveira,Luís Flávio Souza; Machado,Michel Mansur; Farias,Fabiane Moreira. |
| ABSTRACT The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ceiba speciose/phytochemistry; Ceiba speciose/antioxidant activity; Phenolic content; Comet assay; DPPH scavenging capacity; Natural medicine; Safety. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200616 |
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| Santos,Karolina Torres; Silva,Fabricio Ocampo da Luz e; Schneider,Leandro Alves; Santos,Carlos Eduardo Rangel dos; Silva,Sue Elle Berro da; Fernandes,Maquelen Blanco; Rocha,Leandro; Oliveira,Luís Flávio Souza de; Machado,Michel Mansur; Moreira,Cleci Menezes. |
| The essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. This study aims to evaluate myocardial contractility and to analyze angiotensin converting enzyme (ACE) and myosin ATPase activities associated with use of this essential oil. In addition, we evaluated the immunotoxicity of E. sulcata essential oil. Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were treated daily for 30 days (10 mg/kg of oil) to evaluate the isometric force of the papillary... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Myrtaceae/adverse effects; Angiotensin-Converting Enzyme Inhibitors/immunology. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100532 |
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