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	Provedor de dados Genet. Mol. Biol. (1) Autor Ahmed,Rashida (1) Azim,M. Kamran (1) Ghias,Kulsoom (1) Khan,Mumtaz J (1) Madhani,Sarosh (1) Razzak,Safina A (1) Rehmani,Sadiq S (1) Mais... Palavra-chave Driver mutation (1) Head and neck squamous cell carcinoma (HNSCC) (1) Novel mutation (1) Pakistani population (1) Whole exome sequencing (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Mutational landscape of head and neck squamous cell carcinomas in a South Asian population Genet. Mol. Biol. Ghias,Kulsoom; Rehmani,Sadiq S; Razzak,Safina A; Madhani,Sarosh; Azim,M. Kamran; Ahmed,Rashida; Khan,Mumtaz J. Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigation of the disease at the genomic level. Whole exome sequencing of HNSCC samples and matched normal genomic DNA analysis (n=7) was performed. Significant somatic single nucleotide variants (SNVs) were identified and pathway analysis performed to determine frequently affected signaling pathways. We identified significant, novel recurrent mutations in ASNS (asparagine synthetase) that may affect substrate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Head and neck squamous cell carcinoma (HNSCC); Whole exome sequencing; Driver mutation; Novel mutation; Pakistani population. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000400526 Registros recuperados: 1 Primeira ... 1 ... Última

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