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Angiotensin-(1-7) potentiates the coronary vasodilatatory effect of bradykinin in the isolated rat heart BJMBR
Almeida,A.P.; Frábregas,B.C.; Madureira,M.M.; Santos,R.J.S.; Campagnole-Santos,M.J.; Santos,R.A.S..
It has been shown that angiotensin-(1-7) (Ang-(1-7)) infusion potentiates the bradykinin (BK)-induced hypotensive response in conscious rats. The present study was conducted to identify Ang-(1-7)-BK interactions in the isolated rat heart perfused according to the Langendorff technique. Hearts were excised and perfused through the aortic stump under a constant flow with Krebs-Ringer solution and the changes in perfusion pressure and heart contractile force were recorded. Bolus injections of BK (2.5, 5, 10 and 20 ng) produced a dose-dependent hypotensive effect. Ang-(1-7) added to the perfusion solution (2 ng/ml) did not change the perfusion pressure or the contractile force but doubled the hypotensive effect of the lower doses of BK. The BK-potentiating...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin-(1-7); Bradykinin; Coronary artery; Rat heart; L-NAME; Prostaglandins; Bradykinin potentiation.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600012
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