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| Silva,Aline Teixeira Maciel e; Magalhães,Cássia Gonçalves; Duarte,Lucienir Pains; Mussel,Wagner da Nova; Ruiz,Ana Lucia Tasca Gois; Shiozawa,Larissa; Carvalho,João Ernesto de; Trindade,Izabel Cristina; Vieira Filho,Sidney Augusto. |
| ABSTRACT The triterpene lupeol (1) and some of its esters are secondary metabolites produced by species of Celastraceae family, which have being associated with cytotoxic activity. We report herein the isolation of 1, the semi-synthesis of eight lupeol esters and the evaluation of their in vitro activity against nine strains of cancer cells. The reaction of carboxylic acids with 1 and DIC/DMAP was used to obtain lupeol stearate (2), lupeol palmitate (3) lupeol miristate (4), and the new esters lupeol laurate (5), lupeol caprate (6), lupeol caprilate (7), lupeol caproate (8) and lupeol 3’,4’-dimethoxybenzoate (9), with high yields. Compounds 1-9 were identified using FT-IR, 1H, 13C-NMR, CHN analysis and XRD data and were tested in vitro for proliferation of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lupeol/in vitro evaluation; Lupeol ester; K-562 cells; XRD method; Antiproliferative effect.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300621 |
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| Espinoza,Joel Toribio; Novak,Robson Schimandeiro; Magalhães,Cássia Gonçalves; Budel,Jane Manfron; Justus,Barbara; Gonçalves,Melissa Marques; Boscardin,Patricia Mathias Döll; Farago,Paulo Vitor; Paula,Josiane de Fátima Padiha De. |
| The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified reverse phase method. Particle size, polydispersity index, zeta potential, as well as the scanning electron microscopy (SEM) morphological aspects of AgNPs and LAgNPs were evaluated. In addition, was used flame atomic absorption spectroscopy to determine the amount of AgNP that was encapsulated in liposomes. The AgNPs presented as amorphous and polydisperse structures, with a mean diameter of 278.46 nm and zeta potential of -18.3 mV. LAgNPs had a mean... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Silver nanoparticles; Aloe vera; Sunlight; Liposomes. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100625 |
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