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Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease BJMBR
Simon,D.; Paludo,C.A.; Ghisleni,G.C.; Manfroi,W.C.; Roisenberg,I..
High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Von Willebrand factor; Coronary artery disease; DNA polymorphisms; Risk factor.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600005
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Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography BJMBR
Manfroi,W.C.; Zago,A.J.; Cruz,R.; Oliveira,J.; Kirschnick,L.S.; Ordovás,K.; Candiago,R.H.; Souza,J.; Ribeiro,L.W.; Leitão,C.; Brizolara,M.L..
Many clinical and epidemiological studies have demonstrated the relationship between serum ferritin and ischemic heart disease. In the present study we evaluated the relationship between coronary heart disease (CHD) and serum ferritin levels in patients submitted to coronary arteriography. We evaluated 307 patients (210 (68.7%) males; median age: 60 years) who were submitted to coronary angiography, measurement of serum ferritin and identification of clinical events of ischemic heart disease. Serum ferritin is reported as quartiles. Ninety-six patients (31.27%) had normal coronary angiography (group 1) and 211 (68.73%) had coronary heart disease (group 2). Of the patients with CHD, 61 (28.9%) had serum ferritin levels higher than 194 ng/ml (4th quartile),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ferritin; Coronary heart disease; Atherosclerosis; Risk factors; Coronary arteriography.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300009
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