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| Bruggemann,Rafaela; Matsuo Orlandi,Janaina; Benati,Fabricio Jose; Faccin,Ligia Carla; Mantovani,Mario Sergio; Nozawa,Carlos; Linhares,Rosa Elisa Carvalho. |
| The aqueous extract of Agaricus blazei Murill ss. Heinem, a basidiomycete native from Brazil, frequently used by popular medicine, mainly in the form of tea, was assessed to its antiviral action against herpes simplex type 1 (HSV-1) and bovine herpes type 1 (BoHV-1) in HEp-2 cell culture. Viral replication inhibition was evaluated by plaque assay and immunofluorescence test. The extract demonstrated virucide action for both viruses, being more effective against HSV-1, inhibiting its infectivity in 78.4 and 73.9% at the concentrations of 50 and 100 µg/mL, respectively moreover, reduction in 47% the number of fluorescent cells was observed for both concentrations. The extract also showed discrete therapeutic activity. These results suggest that A. blazei... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Agaricus blazei; BoHV-1; HSV-1; Antiviral activity. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000400029 |
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