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| Ren,Yachao; Jiang,Lei; Yang,Shuman; Gao,Sainan; Yu,Hui; Hu,Jie; Hu,Dandan; Mao,Wenbin; Peng,Haisheng; Zhou,Yulong. |
| ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chitosan/gelatin complex film/drugs coating; Chitosan/multilayer coating system/drugs coating; Drugs/delivery system/colon-targeted; Tablets/bilayer-coated. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200239 |
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| Ren,Yachao; Jiang,Lei; Yang,Shuman; Gao,Sainan; Yu,Hui; Hu,Jie; Hu,Dandan; Mao,Wenbin; Peng,Haisheng; Zhou,Yulong. |
| ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chitosan/evaluation; Chistosan/evaluation/gelatin complex film; Drugs/administration; Drugs/delivery system/Colon-targeting; Tablets/bilayer-coated. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100601 |
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