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Role of renin-angiotensin system in development of heart failure induced by myocardial infarction in rats Anais da ABC (AABC)
Trindade,Daniel C.; Trindade,Raquel C.; Marassi,Michelle P.; Martins,Ornélia P.P.R.; Costa-e-Sousa,Ricardo H.; Mattos,Elisabete C.; Marinho-Jr.,Alcides; Reis,Luís C.; Olivares,Emerson L..
We investigated the morphologic and functional changes of infarcted rat hearts under a paradigm of angiotensinconverting enzyme inhibition. Myocardial infarction was induced by left coronary artery ligation and a control group (SHAM) underwent sham-operation. Infarcted rats received normal drinking water with (CAP group) or without (INF group) captopril. Functional assessment was performed by electro (ECG) and echocardiogram (ECHO) just before and 21 days after surgery. The ECG of INF and CAP showed similar values and resembled healed infarct after surgery. The most outstanding differences between INF and CAP were the prevention of the increase of P-wave and attenuation both in rightward deviation of the QRS axis and Q-wave amplitude in CAP compared with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial infarction; Electrocardiogram; Echocardiogram; Renin-angiotensin system; Captopril.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200008
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