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	Provedor de dados BJMBR (2) Autor Marques,S.B.D. (2) Caillat-Zucman,S. (1) Corghi,D.B. (1) Gonçales Jr.,F.L. (1) Gonçales,N.S.L. (1) Lieber,S.R. (1) Pavin,E.J. (1) Persoli,L.B. (1) Volpini,W. (1) Mais... Palavra-chave Chronic hepatitis C (1) DNA typing (1) Genetic markers (1) HLA DR/DQ (1) HLA class II (1) HLA genotyping PCR (1) HLA-DRB1 (1) Hepatitis C virus (1) Insulin-dependent diabetes mellitus (1) Interferon treatment (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Distribution of the human leukocyte antigen class II alleles in Brazilian patients with chronic hepatitis C virus infection BJMBR Corghi,D.B.; Gonçales,N.S.L.; Marques,S.B.D.; Gonçales Jr.,F.L.. Hepatitis C virus (HCV) infection is a global medical problem. The current standard of treatment consists of the combination of peginterferon plus ribavirin. This regimen eradicates HCV in 55% of cases. The immune response to HCV is an important determinant of disease evolution and can be influenced by various host factors. HLA class II may play an important role in immune response against HCV. The objective of the present study was to determine the distribution of HLA class II (DRB1 and DQB1) alleles, their association with chronic HCV infection and their response to interferon therapy. One hundred and two unrelated white Brazilian patients with chronic HCV infection, 52 responders (45 males and 7 females) and 50 non-responders (43 males and 7 females) to... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA class II; HLA DR/DQ; HLA genotyping PCR; Hepatitis C virus; Chronic hepatitis C; Interferon treatment. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000009 Distribution of HLA-DRB1 alleles in a mixed population with insulin-dependent diabetes mellitus from the Southeast of Brazil BJMBR Marques,S.B.D.; Volpini,W.; Caillat-Zucman,S.; Lieber,S.R.; Pavin,E.J.; Persoli,L.B.. HLA class II genes are strongly associated with susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). The present study reports the HLA-DRB1 genotyping of 41 IDDM patients and 99 healthy subjects from the Southeast of Brazil (Campinas region). Both groups consisted of an ethnic mixture of Caucasian, African Negro and Amerindian origin. HLA-DRB1*03 and *04 alleles were found at significantly higher frequencies among IDDM patients compared to the controls (DRB1*03: 48.8% vs 18.2%, P<0.005, RR = 4.27; DRB1*04: 43.9% vs 15.1%, P<0.008, RR = 4.37) and were associated with a susceptibility to the disease. DRB1*03/*04 heterozygosity conferred a strong IDDM risk (RR = 5.44). In contrast, the HLA-DRB1*11 allele frequency was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Insulin-dependent diabetes mellitus; Genetic markers; DNA typing; HLA-DRB1. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300005 Registros recuperados: 2 Primeira ... 1 ... Última

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