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Quantitative studies of the vasculature of the carotid body in the chronically hypoxic rat BJMBR
Clarke,J.A.; Daly,M. de B.; Marshall,J.M.; Ead,H.W.; Hennessy,E.M..
The carotid bodies of rats made chronically hypoxic by breathing 12% O2 in a normobaric chamber (inspired PO2 91 mmHg) were compared with those of controls. Serial 5-µm sections of the organs were examined using an interactive image analysis system. The total volume of the carotid bodies was increased by 64%. The total vascular volume rose by 103% and was likely due to an increase in size of the large vessels (>12 µm lumen diameter) because the small vessel (5-12 µm lumen diameter) volume did not increase significantly while the small vessel density tended to decrease. The extravascular volume was increased by 57%. Expressed as a percentage of the total volume of the organ, the total vascular volume did not change, but the small vessel volume was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rat carotid body; Morphology; Chronic hypoxia.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300012
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Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia BJMBR
Marshall,J.M..
This review describes the ways in which the primary bradycardia and peripheral vasoconstriction evoked by selective stimulation of peripheral chemoreceptors can be modified by the secondary effects of a chemoreceptor-induced increase in ventilation. The evidence that strong stimulation of peripheral chemoreceptors can evoke the behavioural and cardiovascular components of the alerting or defence response which is characteristically evoked by novel or noxious stimuli is considered. The functional significance of all these influences in systemic hypoxia is then discussed with emphasis on the fact that these reflex changes can be overcome by the local effects of hypoxia: central neural hypoxia depresses ventilation, hypoxia acting on the heart causes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoxia; Adenosine; Chemoreceptors; Vasodilatation; Noradrenaline.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700002
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