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	Provedor de dados Nature Precedings (4) Autor Martin Piskacek (4) Joachim Lipp (1) Manfred Koranda (1) Palavra-chave Genetics & Genomics (4) Molecular Cell Biology (1) Tipo do documento Manuscript (4) Ano 2009 (4) País United Kingdom (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Rsp5 promotes Gene Activation mediated by 9aaTAD Transcription Factors Oaf1 and Gal4 Nature Precedings Joachim Lipp; Manfred Koranda; Martin Piskacek. Nine-amino-acid transactivation domain, 9aaTAD, defines a large superfamily of yeast and mammals transcription factors. The transactivation of the 9aaTAD has been addressed to multiple general co-activators TAF9, MED15, CBP and p300. We demonstrate for the 9aaTAD transcription factors Oaf1 and Gal4 functional and physical interaction with E3-Ubiquitin Ligase Rsp5. The Rsp5-associations with RNA polymerase II and TFIID were reported previously. Tipo: Manuscript Palavras-chave: Genetics & Genomics; Molecular Cell Biology. Ano: 2009 URL: http://precedings.nature.com/documents/3968/version/1 Common Transactivation Motif 9aaTAD recruits multiple general co-activatorsTAF9, MED15, CBP and p300 Nature Precedings Martin Piskacek. More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation domain, TAD, mediates the interaction of transcription factors with general transcriptional co-activators such as TAF9, MED15, CBP and p300. Recently reported NMR-data for interactions of these co-activators with transcription factors reveal tightly binding of KIX and TAZ domains to common 9aaTAD motif. Nine-amino-acid Trans-Activation Domain, 9aaTAD, defines a transactivation domain common to a large super-family of eukaryotic transcription factors represented in yeast by Gal4, Oaf1, Pdr1, Rtg3, Pho4, Gln3, Gcn4 and in mammals by p53, E2A, NFAT, NFkB, HSF1, NF-IL6, MLL, EBNA2, VP16. The 9aaTAD family was derived from... Tipo: Manuscript Palavras-chave: Genetics & Genomics. Ano: 2009 URL: http://precedings.nature.com/documents/3488/version/1 Common Transactivation Motif 9aaTAD recruits multiple general co-activators TAF9, MED15, CBP and p300 Nature Precedings Martin Piskacek. More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation domain, TAD, mediates the interaction of transcription factors with general transcriptional co-activators such as TAF9, MED15, CBP and p300. Recently reported NMR-data for interactions of these co-activators with transcription factors reveal tightly binding of KIX and TAZ domains to common 9aaTAD motif. Nine-amino-acid Trans-Activation Domain, 9aaTAD, defines a transactivation domain common to a large super-family of eukaryotic transcription factors represented in yeast by Gal4, Oaf1, Pdr1, Rtg3, Pho4, Gln3, Gcn4 and in mammals by p53, E2A, NFAT, NFkB, HSF1, NF-IL6, MLL, EBNA2, VP16. The 9aaTAD family was derived from... Tipo: Manuscript Palavras-chave: Genetics & Genomics. Ano: 2009 URL: http://precedings.nature.com/documents/3488/version/2 9aaTAD Prediction result (2006) Nature Precedings Martin Piskacek. Recently reported, 9aaTAD transcription factors p53, VP16, MLL/ALL, E2A, HSF1, NF-IL6, NFAT1 and NF-kB interact directly with the general coactivator CBP/p300 aside from already referred TAF9. All four domains of CBP/p300 - KIX, TAZ1, TAZ2 and IBiD provide multiple interactions with 9aaTADs, e.g. p53. Annotation of predicted 9aa TAD using Pattern search ScanProsite on ExPASy and relevant experimental data are listed. Tipo: Manuscript Palavras-chave: Genetics & Genomics. Ano: 2009 URL: http://precedings.nature.com/documents/3984/version/1 Registros recuperados: 4 Primeira ... 1 ... Última

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