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| Benzaken,Adele Schwartz; Girade,Renato; Catapan,Elisa; Pereira,Gerson Fernando Mendes; Almeida,Elton Carlos de; Vivaldini,Simone; Fernandes,Neide; Razavi,Homie; Schmelzer,Jonathan; Ferraz,Maria Lucia; Ferreira,Paulo Roberto Abrão; Pessoa,Mario Guimarães; Martinelli,Ana; Souto,Francisco José Dutra; Walsh,Nick; Mendes-Correa,Maria Cassia. |
| ABSTRACT Introduction and aim: Hepatitis C is a key challenge to public health in Brazil. The objective of this paper was to describe the Brazilian strategy for hepatitis C to meet the 2030 elimination goal proposed by World Health Organization (WHO). Methods: A mathematical modeling approach was used to estimate the current HCV-infected Brazilian population, and to evaluate the relative costs of two different scenarios to address HCV disease burden in Brazil: (1) if no further changes are made to the HCV treatment program in Brazil; (2) where the WHO targets for 2030 elimination are met through diagnosis and treatment efforts peaking before 2024. Results: An anti-HCV prevalence of 0.53% was calculated for the total population. It was estimated that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Hepatitis C elimination; Hepatitis C disease burden; Brazil. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300182 |
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| Ferreira,Paulo Roberto Abrão; Silva,Mariliza Henrique da; Brandão-Melo,Carlos Eduardo; Rezende,Rosamar Eulira; Gonzalez,Mário; Reuter,Tânia; Urbaez,Jose David; Gianini,Reinaldo Jose; Martinelli,Ana; Mendes-Correa,Maria Cássia. |
| Introduction: in Brazil, chronic hepatitis C in patients coinfected with the human immunodeficiency virus (HIV) is treated with pegylated interferon (Peg-IFN) and ribavirin (RBV). However, few studies have evaluated the effectiveness of this treatment in this particular population. The identification of the factors that predict sustained virological response (SVR) under current clinical practice would enable clinicians to more accurately estimate the probability of achieving an SVR and therefore utilize the appropriate therapeutics, especially in the era of direct-acting antiviral (DAA) agents.Aims: the primary aim of our study was to determine the SVR rate under current clinical practice. The secondary aims were as follows: (1) to determine the factors... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Interferon Ribavirin HCV; HIV. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100015 |
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