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Pharmacoepidemiological profile and polypharmacy indicators in elderly outpatients BJPS
Baldoni,André de Oliveira; Ayres,Lorena Rocha; Martinez,Edson Zangiacomi; Dewulf,Nathalie de Lourdes Sousa; Santos,Vânia dos; Obreli-Neto,Paulo Roque; Pereira,Leonardo Régis Leira.
This cross-sectional study was carried out with 1000 elderly outpatients assisted by a Basic Health District Unit (UBDS) from the Brazilian Public Health System (SUS) in the municipality of Ribeirão Preto. We analyzed the clinical, socioeconomic and pharmacoepidemiological profile of the elderly patients in order to identify factors associated with polypharmacy amongst this population. We used a truncated negative binomial model to examine the association of polypharmacy with the independent variables of the study. The software SAS was used for the statistical analysis and the significance level adopted was 0.05. The most prevalent drugs were those for the cardiovascular system (83.4%). There was a mean use of seven drugs per patient and 47.9% of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pharmacoepidemiology; Elderly/use of drugs; Polypharmacy; Drugs/rational use; Public Health System.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300006
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Influence of the clinical profile of patients with refractory epilepsy on lamotrigine plasma concentration BJPS
Baldoni,André Oliveira; Freitas-Lima,Priscila; Alexandre,Veriano; Ferreira,Flávia Isaura de Santi; Martinez,Edson Zangiacomi; Queiroz,Regina Helena Costa; Sakamoto,Americo Ceiki; Pereira,Leonardo Regis Leira.
ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil were performed. The multiple linear regression model was used to verify association between the LTG plasma concentrations and the independent variables. Covariance analysis was used to compare the mean LTG plasma concentration among the co-medication groups. The LTG plasma concentration was associated both with the LTG dosage (mg/kg/day) (p=0.0096) and with the use of first generation antiepileptic drugs...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lamotrigine; Refractory Epilepsy; Drug interaction; Therapeutic drug monitoring..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200624
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