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| Martini,Rosiéli; Hörner,Rosmari; Graichen,Daniel Ângelo Sganzerla. |
| Abstract In recent years, several studies have described the clinical impact of bacterial infection associated with transfusion of platelet concentrates (PCs). Among the blood components, PCs are responsible for the highest rates of bacterial contamination as well as septic transfusion reactions. We assessed antimicrobial susceptibility profile, resistance to methicillin (MRCoNS), and resistance to macrolides, lincosamides and streptogramins of group B (MLSB) of 16 coagulase-negative staphylococci (CoNS) isolates from an investigation in 691 PCs bags. We then compared conventional and automated phenotypic methods, disc diffusion test (DD) and VITEK(r) 2, respectively as well as phenotypic and genotypic methods (Polymerase Chain Reaction - PCR). All CoNS... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bacterial resistance; Staphylococcus sp; Platelet concentrates; MecA; Erm.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100609 |
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| Nunes,Melise Silveira; Garzon,Litiérri Razia; Rampelotto,Roberta Filipini; Tizotti,Maísa Kräulich; Martini,Rosiéli; Locatelli,Aline; Barbosa,Marcelo; Hörner,Manfredo; Hörner,Rosmari. |
| ABSTRACT The enhancement of anti-leukemia therapy and the treatment of infections caused by multidrug-resistant pathogens are major challenges in healthcare. Although a large arsenal of drugs is available, many of these become ineffective, and as a result, the discovery of new active substances occurs. Notably, triazenes (TZCs) have been consolidated as a promising class of compounds, characterized by significant biological activity, especially antiproliferative and antimicrobial properties. The aim of this study is the synthesis and characterization of a new triazenide complex of gold (I), as well as the in vitro assessment of its antiproliferative activity against the K562 cell line (Chronic Myeloid Leukemia), and antibacterial activity against bacterial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Triazenes/synthesis/characterization/biological activity; TZC/Gold ion complexed; Chronic myeloid leukemia; Antibacterial activity. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400617 |
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