Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Nature Precedings (2) Autor Matthew B. Pomrenze (2) Michael V. Baratta (2) Brian A. Cadle (1) Donald C. Cooper (1) Donald C. Cooper (1) Peter Dobelis (1) Samuel D. Dolzani (1) Shinya Nakamura (1) Mais... Palavra-chave Biotechnology (2) Genetics & Genomics (2) Neuroscience (2) Molecular Cell Biology (1) Pharmacology (1) Tipo do documento Manuscript (2) Ano 2012 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation Nature Precedings Matthew B. Pomrenze; Michael V. Baratta; Brian A. Cadle; Donald C. Cooper. Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost mouse self-administration catheter assembly and protocol that that can be used to assess a variety of drugs of abuse with a variety of protocols. We describe a method for intravenous catheter fabrication that allows for efficient and long-lasting intravenous drug delivery. The intravenous catheters remained intact and patent for several weeks allowing us to establish stable maintenance of cocaine acquisition. This was followed by a dose response study in the... Tipo: Manuscript Palavras-chave: Biotechnology; Genetics & Genomics; Molecular Cell Biology; Neuroscience; Pharmacology. Ano: 2012 URL: http://precedings.nature.com/documents/7040/version/1 Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex Nature Precedings Michael V. Baratta; Shinya Nakamura; Peter Dobelis; Matthew B. Pomrenze; Samuel D. Dolzani; Donald C. Cooper. A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information among prefrontal neuronal subtypes is the inability to manipulate the electrical activity of genetically defined cell types over behaviorally relevant timescales and activity patterns. To address these constraints, we present here a simple approach for selective activation of prefrontal excitatory neurons in both in vitro and in vivo preparations. Rat prelimbic pyramidal neurons were genetically targeted to express a... Tipo: Manuscript Palavras-chave: Biotechnology; Genetics & Genomics; Neuroscience. Ano: 2012 URL: http://precedings.nature.com/documents/7102/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco