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	Provedor de dados BJPS (1) Autor Laporta,Luciane Varini (1) Maurer,Marcela (1) Rolim,Clarice Madalena Bueno (1) Rubenick,Jaqueline Bandeira (1) Rubim,Alexandre Machado (1) Palavra-chave Amiodarone HCl/evaluation (1) Amiodarone HCl/solubility (1) Cyclodextrins /thermodynamic studies (1) Cyclodextrins/inclusion complexes (1) Dissolution rate (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation BJPS Rubim,Alexandre Machado; Rubenick,Jaqueline Bandeira; Maurer,Marcela; Laporta,Luciane Varini; Rolim,Clarice Madalena Bueno. ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffraction, differential scanning calorimetry and scanning electronic microscopy. Thermodynamic studies demonstrate that the inclusion complexes of drug into different cyclodextrins were an exothermic process that occurred spontaneously. Water solubility and drug dissolution rates were significantly increased after the formation of inclusion complexes with the cyclodextrins evaluated in relation to the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Amiodarone HCl/evaluation; Amiodarone HCl/solubility; Cyclodextrins/inclusion complexes; Cyclodextrins /thermodynamic studies; Dissolution rate. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200607 Registros recuperados: 1 Primeira ... 1 ... Última

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