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	Provedor de dados BJMBR (2) Autor Belló-Klein,A. (2) Mazzotti,N.G. (2) Araújo,A.S.R. (1) Biolo,A. (1) Clausell,N. (1) Fernandes,T.R.G. (1) Gutierrez,L.L.P. (1) Klipel,R.B. (1) Llesuy,S.F. (1) Martins,S. (1) Rohde,L.E. (1) Rosa,A.S. (1) Mais... Palavra-chave Adrenergic receptor (1) Antioxidant enzymes (1) Heart failure (1) Heavy metals (1) HgCl2 (1) Lipid peroxidation (1) Polymorphisms (1) Total radical-trapping antioxidant potential (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2006 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Peripheral markers of oxidative stress in chronic mercuric chloride intoxication BJMBR Gutierrez,L.L.P.; Mazzotti,N.G.; Araújo,A.S.R.; Klipel,R.B.; Fernandes,T.R.G.; Llesuy,S.F.; Belló-Klein,A.. The present study was designed to evaluate the time course changes in peripheral markers of oxidative stress in a chronic HgCl2 intoxication model. Twenty male adult Wistar rats were treated subcutaneously daily for 30 days and divided into two groups of 10 animals each: Hg, which received HgCl2 (0.16 mg kg-1 day-1), and control, receiving the same volume of saline solution. Blood was collected at the first, second and fourth weeks of Hg administration to evaluate lipid peroxidation (LPO), total radical trapping antioxidant potential (TRAP), and superoxide dismutase (Cu,Zn-SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase (CAT). HgCl2 administration induced a rise (by 26%) in LPO compared to control (143 ± 10 cps/mg... Tipo: Info:eu-repo/semantics/other Palavras-chave: Heavy metals; Antioxidant enzymes; Lipid peroxidation; Total radical-trapping antioxidant potential; HgCl2. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600009 The role of adrenergic receptor polymorphisms in heart failure BJMBR Biolo,A.; Rosa,A.S.; Mazzotti,N.G.; Martins,S.; Belló-Klein,A.; Rohde,L.E.; Clausell,N.. The main function of the cardiac adrenergic system is to regulate cardiac work both in physiologic and pathologic states. A better understanding of this system has permitted the elucidation of its role in the development and progression of heart failure. Regardless of the initial insult, depressed cardiac output results in sympathetic activation. Adrenergic receptors provide a limiting step to this activation and their sustained recruitment in chronic heart failure has proven to be deleterious to the failing heart. This concept has been confirmed by examining the effect of ß-blockers on the progression of heart failure. Studies of adrenergic receptor polymorphisms have recently focused on their impact on the adrenergic system regarding its adaptive... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Adrenergic receptor; Polymorphisms. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000003 Registros recuperados: 2 Primeira ... 1 ... Última

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