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| Seara,F.A.C.; Araujo,I.G.; Império,G.E.; Marassi,M.P.; Silva,A.C.M.; Mecawi,A.S.; Reis,L.C.; Olivares,E.L.. |
| Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats. Despite a sustained and dramatic fall in serum T4 concentrations (60–70%), the serum T3 concentration fell only transiently in the first week post-infarction (53%) and returned to control levels at 8 and 12 weeks after surgery compared to the Sham group (P<0.05). Brown adipose tissue (BAT) D2 activity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Myocardial infarction; Thyroid hormone; Deiodinase; Beta-blocker; Rats. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000609 |
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| Antunes-Rodrigues,J.; Ruginsk,S.G.; Mecawi,A.S.; Margatho,L.O.; Cruz,J.C.; Vilhena-Franco,T.; Reis,W.L.; Ventura,R.R.; Reis,L.C.; Vivas,L.M.; Elias,L.L.K.. |
| Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypothalamus; Gaseous neuromodulators; Neuropeptides; Endocannabinoids; Glial cells; Neurotransmitters. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400327 |
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