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The Effect of Gestational Diabetes Mellitus on Sciatic Nerve in Adult Offspring Rats International Journal of Morphology
Ameri,Mehdi; Ghafari,Soraya; Nazari,Zahra; Mehdizadeh,Mehdi; Shekari,Majid Asadi; Golalipour,Mohammadjafar.
Gestational diabetes mellitus (GDM) is one form of diabetes affect approximately 7 % of pregnancies. Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is associated with loss of nerve fibers, myelin abnormalities and significant decrease in the expression of myelin basic protein (MBP) in peripheral nerves. This study was done to determine the effect of induced diabetes during pregnancy on sciatic nerve in adult rat offspring. In this study, wistar rats' dams were allocated to control and diabetic groups. Diabetic rats were received 40 mg/kg/body weight of streptozotocin (STZ) on the first day of gestation. Six offspring of each group were randomly selected on 12 weeks postnatal and histopathological changes in their nerve...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; Sciatic nerve; Myelin basic protein; Schwannocytus (Schwann cell).
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100026
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