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| Oliveira,Karen M; Silva,Carla Maria O; Lavor,Mário Sérgio L; Rosado,Isabel R; Fukushima,Fabíola B; Assumpção,Anna Luiza FV; Neves,Saira MN; Motta,Guilherme R; Garcia,Fernanda F; Gomez,Marcus Vinícius; Melo,Marília M; Melo,Eliane G. |
| Background:Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitromodels of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. However, previous clinical studies with MVIIC demonstrated that clinical side effects might limit the usefulness of this drug and there is no research on its systemic effects. Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. Rats were treated with placebo or MVIIC (at doses of 15, 30, 60 or 120... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Conus magus; Cone snail; Histopathology; Hematology; Biochemistry. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200311 |
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