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	Provedor de dados BJMBR (1) Autor Fonteles,M.C. (1) Jorge,M.C.M. (1) Menezes,D.B. (1) Monteiro,H.S.A. (1) Nobre,A.C.L. (1) Palavra-chave Kidney (1) Microcystin-LR (1) Perfused kidney (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 1999 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Effects of microcystin-LR in isolated perfused rat kidney BJMBR Nobre,A.C.L.; Jorge,M.C.M.; Menezes,D.B.; Fonteles,M.C.; Monteiro,H.S.A.. Microcystin is a hepatotoxic peptide which inhibits protein phosphatase types 1 and 2A. The objective of the present study was to evaluate the physiopathologic effects of microcystin-LR in isolated perfused rat kidney. Adult Wistar rats (N = 5) of both sexes (240-280 g) were utilized. Microcystin-LR (1 µg/ml) was perfused over a period of 120 min, during which samples of urine and perfusate were collected at 10-min intervals to determine the levels of inulin, sodium, potassium and osmolality. We observed a significant increase in urinary flow with a peak effect at 90 min (control (C) = 0.20 ± 0.01 and treated (T) = 0.32 ± 0.01 ml g-1 min-1, P<0.05). At 90 min there was a significant increase in perfusate pressure (C = 129.7 ± 4.81 and T = 175.0 ±... Tipo: Info:eu-repo/semantics/article Palavras-chave: Microcystin-LR; Kidney; Perfused kidney. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800008 Registros recuperados: 1 Primeira ... 1 ... Última

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