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	Provedor de dados BJMBR (1) Autor Cabral,D.F. (1) Carvalho-Salles,A.B. (1) Hackel,C. (1) Mesquita,J.C. (1) Ribeiro,M.L. (1) Santos,A. (1) Mais... Palavra-chave 5'Untranslated region (1) DNA sequence alterations (1) Human androgen receptor gene (1) Promoter region (1) Prostate cancer (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2004 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Rarity of DNA sequence alterations in the promoter region of the human androgen receptor gene BJMBR Cabral,D.F.; Santos,A.; Ribeiro,M.L.; Mesquita,J.C.; Carvalho-Salles,A.B.; Hackel,C.. The human androgen receptor (AR) gene promoter lies in a GC-rich region containing two principal sites of transcription initiation and a putative Sp1 protein-binding site, without typical "TATA" and "CAAT" boxes. It has been suggested that mutations within the 5'untranslated region (5'UTR) may contribute to the development of prostate cancer by changing the rates of gene transcription and/or translation. In order to investigate this question, the aim of the present study was to search for the presence of mutations or polymorphisms at the AR-5'UTR in 92 prostate cancer patients, where histological diagnosis of adenocarcinoma was established in specimens obtained from transurethral resection or after prostatectomy. The AR-5'UTR was amplified by PCR from... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human androgen receptor gene; Promoter region; Prostate cancer; 5'Untranslated region; DNA sequence alterations. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200004 Registros recuperados: 1 Primeira ... 1 ... Última

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