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	Provedor de dados Nature Precedings (2) Autor Michael J. Owen (2) Belinda Martin (1) Brad Nicholas (1) Brian Lawlord (1) Dawn C. Wimpory (1) Gillian Hamilton (1) John Powell (1) Julie Williams (1) Michael Gill (1) Michelle Lupton (1) Nicola Archer (1) Paul hollingworth (1) Petroula Proitsi (1) Simon Lovestone (1) Suzanne Reeves (1) Thomas Caspari (1) Mais... Palavra-chave Genetics & Genomics (2) Bioinformatics (1) Neuroscience (1) Tipo do documento Manuscript (2) Ano 2009 (1) 2008 (1) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD). Nature Precedings Petroula Proitsi; Michelle Lupton; Suzanne Reeves; Gillian Hamilton; Nicola Archer; Belinda Martin; Paul hollingworth; Brian Lawlord; Michael Gill; Michael J. Owen; Julie Williams; Simon Lovestone; John Powell. Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic association studies are contradictory. We used 1008 probable AD patients from the UK and applied a Multiple Indicators Multiple Causes (MIMIC) approach to investigate the effect of 11 polymorphisms in the serotonergic and dopaminergic systems, on four behavioural sub-phenotypes, namely "psychosis"," moods", "agitation" and "behavioural dyscontrol", as well as on 12 NPI items. Significant findings included the association of DRD1 A48G with "psychosis" (p=0.037), the association of... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience. Ano: 2009 URL: http://precedings.nature.com/documents/3896/version/1 Autism-associated SNPs in the clock genes _npas2_, _per1_ and the homeobox gene _en2_ alter DNA sequences that show characteristics of microRNA genes. Nature Precedings Brad Nicholas; Michael J. Owen; Dawn C. Wimpory; Thomas Caspari. Intronic single nucleotide polymorphisms (SNPs) in the clock genes _npas2_ and _per1_ and the homeobox gene _en2_ are reported to be associated with autism. This bioinformatics analysis of the intronic regions which contain the autism-associated SNPs rs1861972 and rs1861973 in _en2_, rs1811399 in _npas2_, and rs885747 in _per1_, shows that these regions encode RNA transcripts with predicted structural characteristics of microRNAs. These microRNA-like structures are disrupted _in silico_ by the presence of the autism enriched alleles of rs1861972, rs1861973, rs1811399 and rs885747 specifically, as compared with the minor alleles of these SNPs. The predicted gene targets of these microRNA-like structures include genes reported to be implicated in autism... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Bioinformatics. Ano: 2008 URL: http://precedings.nature.com/documents/2366/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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