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Analysis of Cancer Omics Data In A Semantic Web Framework Nature Precedings
Matthew Holford; James P. McCusker; Kei Cheung; Michael Krauthammer.
Our work concerns the elucidation of the cancer (epi)genome, transcriptome and proteome to better understand the complex interplay between a cancel cell's molecular state and its response to anti-cancer therapy. To study the problem, we have previously focused on data warehousing technologies and statistical data integration. In this paper, we present recent work on extending our analytical capabilities using Semantic Web technology. A key new component presented here is a SPARQL endpoint to our existing data warehouse. This endpoint allows the merging of observed quantitative data with existing data from semantic knowledge sources such as Gene Ontology (GO). We show how such variegated quantitative and functional data can be integrated and...
Tipo: Presentation Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics.
Ano: 2010 URL: http://precedings.nature.com/documents/5391/version/1
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