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| Aminjafari,Akram; Miroliaei,Mehran; Angelova,Violina T; Emamzadeh,Rahman; Djukic,Mirjana M; Djuric,Ana; Saso,Luciano. |
| Background: Synthesized aminocoumarins are heterocyclic compounds possessing potential for the treatment of insulin-dependent diabetes mellitus with unexplored anti-glycative action. Results: In this study 4-aminocoumarin derivatives (4-ACDs) were evaluated in vitro for antiglycation (AG) activities by using the human serum albumin (HSA)/glucose system, for 8 weeks of incubation. The glycation and conformational alteration of HSA in the presence of the tested compounds were evaluated by Congo red assay, fluorescence and circular dichroism spectroscopy. The antioxidant (AO) capacity were also tested by four different assays including: DPPH (2,2'-diphenyl-1-picrylhydrazyl radical), ABTS (2,2-azinobis (3-ethylbenzothiazoline-6-sulphonate) diammonium salt),... |
| Tipo: Journal article |
Palavras-chave: Anti-glycation agents Diabetes; 4-Aminocoumarin derivatives Congo red Spectropolarimetry Spectrofluorimetry. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000600007 |
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