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	Provedor de dados BABT (1) Autor Al-Fayez,Musaed (1) Al-Rasheed,Nawal M. (1) Al-Rasheed,Nouf M. (1) Ali,Hanaa M. (1) Fadda,Laila (1) Hasan,Iman H. (1) Mohamad,Raeesa A. (1) Mais... Palavra-chave Acetaminophen (1) Cyclooxygenase-2 (1) Thymoquinone (1) Α-Lipoic acid (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Hepatoprotective Role of α-Lipoic acid and Thymoquinone in Acetaminophen- Induced Liver Injury: Down-Regulation of COX-2 and flt-1 Expression BABT Al-Rasheed,Nawal M.; Fadda,Laila; Al-Rasheed,Nouf M.; Hasan,Iman H.; Ali,Hanaa M.; Al-Fayez,Musaed; Mohamad,Raeesa A.. ABSTRACT Acetaminophen (APAP) is a widely-used analgesic, while toxic doses of which induce liver injury. Inducible cyclooxygenase-2 (COX-2) is derived prostaglandins which play an anti-inflammatory role in acetaminophen-induced hepatotoxicity. Selective activation of vascular endothelial growth factor (VEGFR1, flt -1) on endothelial cells increased mRNA levels of hepatocyte mitogens (IL-6) and hepatocyte growth factor leading to prosurvival effects on hepatocytes. The aim of this study was to compare the hepatoprotective effect of N-acetylcysteine (NAC; the antidote for APAP) with that of α-Lipoic acid (ALA) and/or Thymoquinone (THQ) either alone or in combination on liver injury induced by APAP. APAP administration elevated most of the previously... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetaminophen; Α-Lipoic acid; Thymoquinone; Cyclooxygenase-2. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100427 Registros recuperados: 1 Primeira ... 1 ... Última

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