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	Provedor de dados BJM (1) Genet. Mol. Biol. (1) Autor Moraes,Karen C.M. (2) Aimbire,Flávio (1) Lyon,Juliana P. (1) Moreira,Leonardo M. (1) Resende,Maria Aparecida de (1) Wilusz,Carol J. (1) Wilusz,Jeffrey (1) Mais... Palavra-chave 3'UTR (1) CUG-BP (1) Candida albicans (1) Clonal reproduction (1) Deadenylation (1) Genotyping systems (1) MRNA decay (1) MRNA stability (1) Microevolution (1) Phenotypic characteristics (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última CUG-BP and 3'UTR sequences influence PARN-mediated deadenylation in mammalian cell extracts Genet. Mol. Biol. Moraes,Karen C.M.; Wilusz,Carol J.; Wilusz,Jeffrey. Several mRNAs have been shown to exhibit distinct patterns of poly(A) shortening prior to their decay in vivo. In this study, we show that individual transcripts also demonstrate distinct patterns of deadenylation in in vitro systems derived from HeLa and Jurkat T cell cytoplasmic extracts. The major patterns observed were slow/synchronous and fast/asynchronous poly(A) tail shortening. For all RNA substrates tested, PARN was shown to be the enzyme responsible for the deadenylation patterns that were observed. Sequences in the 3' untranslated regions influenced the deadenylation pattern. Using a fragment of the 3'UTR of the c-fos mRNA as a model, the interaction of CUG-BP, the human homolog of EDEN-BP - a protein previously implicated in regulated... Tipo: Info:eu-repo/semantics/article Palavras-chave: MRNA decay; Deadenylation; MRNA stability; 3'UTR; CUG-BP. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400024 Candida albicans: genotyping methods and clade related phenotypic characteristics BJM Lyon,Juliana P.; Moraes,Karen C.M.; Moreira,Leonardo M.; Aimbire,Flávio; Resende,Maria Aparecida de. Several molecular methods, such as Southern blotting hybridization, Multilocus Sequence Typing, and DNA microsatellite analysis, have been employed to genotype Candida albicans. The genotype analysis allows to group strains in clades, that is, a group composed of one ancestor and its descendants. These genotype studies demonstrate that clades distribution is influenced by geographic area as well as that antifungal resistance is associated with particular clades. These findings suggested that C. albicans reproduces mainly in a clonal manner, with certain degree of DNA microevolution. Additionally, virulence factors and site of isolation have also been associated with clade specificity. The present article is a brief review about the methods used for Candida... Tipo: Info:eu-repo/semantics/article Palavras-chave: Candida albicans; Clonal reproduction; Microevolution; Genotyping systems; Phenotypic characteristics. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000400003 Registros recuperados: 2 Primeira ... 1 ... Última

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