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Screening for CLCN5 mutation in renal calcium stone formers patients Anais da ABC (AABC)
Rebelo,Maria Alice P.; Tostes,Vera; Araújo,Nordeval C.; Martini,Sabrina V.; Botelho,Bruno F.; Guggino,William B.; Morales,Marcelo M..
Thirty-five patients (23 males and 12 females), age 35 ± 13 years old, presenting either idiopathic calcium nephrolithiasis, nephrocalcinosis or mild renal failure with idiopathic calcium nephrolithiasis were selected for the analysis of low molecular weight proteinuria and the possible mutations occurrence in the chloride channel gene CLCN5. The urinary ratio of beta2-microglobulin and creatinine (beta2M/Cr) was very high in a transplanted woman with nephrocalcinosis (>3.23 mg/mmol) and slightly high in five patients (>0.052 or < 1.0 mg/mmol) with multiple urological manipulations. Other studied patients showed beta2M/Cr ratio at normal range (0.003-0.052 mg/mmol) without gender difference (p > 0.05). Mutation analysis of CLCN5 gene was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nephrolithiasis; Nephrocalcinosis; Low-molecular-weight proteinuri; CLCN5 mutation.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100007
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Rhodnius prolixus Malpighian tubules and control of diuresis by neurohormones Anais da ABC (AABC)
Martini,Sabrina V.; Nascimento,Suzete B.; Morales,Marcelo M..
Rhodnius prolixus Malpighian tubules (MTs) are a good model for fluid and ion secretion studies in view of the dramatic postprandial diuresis, which follows its massive blood meals. Ingestion of a blood meal equals to 10-12 times their initial body mass, leads to rapid activation of high output by excretory system, which eliminates 40-50% of the fluid mass. Secretion of ions and water is stimulated 1000-fold by serotonin and diuretic hormone. These hormones cooperate synergistically to activate adenylate cyclase activity from MTs cells, which increase the level of intracellular cAMP. The anti-diuretic hormones have also an important role in the fluid maintenance of Rhodnius prolixus. Several hours after insect feeding occurs a reduction in urine flow, that...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Malpighian tubules; Rhodnius prolixus; Hormones; Fluid secretion.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100011
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