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	Provedor de dados Genet. Mol. Biol. (1) Autor Moreira,Aline Santos (1) Pimentel,Beatriz Jatobá (1) Seuánez,Héctor N. (1) Stefanoff,Cláudio Gustavo (1) Zalcberg,Ilana Renault (1) Palavra-chave Chronic lymphocytic leukaemia (1) Immunoglobulin rearrangements (1) Somatic hypermutation (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2008 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Use of V H, D and J H immunoglobulin gene segments in Brazilian patients with chronic lymphocytic leukaemia (CLL) Genet. Mol. Biol. Pimentel,Beatriz Jatobá; Stefanoff,Cláudio Gustavo; Moreira,Aline Santos; Seuánez,Héctor N.; Zalcberg,Ilana Renault. Chronic lymphocytic leukaemia (CLL) is a haematological malignancy for which reliable prognostic markers are needed in view of its clinical heterogeneity. In approximately 50% of CLL patients, immunoglobulin (Ig) rearrangements are modified by somatic hypermutation (SHM), a process that represents a reliable prognostic indicator of favourable progression. In this study, we investigated SHM in 37 Brazilian CLL patients and identified the preferential involvement of specific immunoglobulin gene families and segments through PCR-amplified fragments or subcloned fragments. Forty-one rearrangements were observed and 37 of them were functional. A 98% homology cut-off with germinal sequences showed 18 patients (48.7%) with SHM. Unmutated cases showed a poorer... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic lymphocytic leukaemia; Immunoglobulin rearrangements; Somatic hypermutation. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400007 Registros recuperados: 1 Primeira ... 1 ... Última

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