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| Gaspar,Pedro; Moreira,José; Kvitko,Katia; Torres,Martiela; Moreira,Ana; Weimer,Tania. |
| Gene polymorphisms of phase I (CYP1A1 and CYP2E of cytochrome P,) and phase II (GSTM1, GSTT1 and GSTP1 of glutathione-S-transferase,) enzymes and the TP53 tumor suppressor gene were studied as markers in a sample of 262 Brazilians of European descent, the sample consisting of 97 patients with non-small-cell lung cancer (NSCLC), 75 patients with chronic obstructive pulmonary disease (COPD) and 90 control individuals. For NSCLC, we found no significant relationship between any of the markers studied and susceptibility to this disease. With respect to COPD, although the distribution of the CYP1A1, GSTM1, GSTP1, GSTT1 and TP53 genotypes was similar to that of the controls the frequency of the CYP2E1*1A/*5B heterozygote was about 6 times higher in COPD patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CYPs; GSTs and TP53 polymorphisms; Chronic obstructive pulmonary disease; Non-small-cell lung cancer; Genetic susceptibility. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200001 |
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