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	Provedor de dados BJMBR (2) Autor Moreira,E.S. (2) Alberto,F.L. (1) Asprino,P.F. (1) Azevedo,L.C.P. (1) Biagini,S. (1) Carvalho,C.R.R. (1) Dale,C.S. (1) Guimarães,G.S. (1) Moysés,C.B. (1) Real,J.M. (1) Schettino,G.P.P. (1) Wendel,S. (1) Mais... Palavra-chave Hemochromatosis (1) Hemorrhage (1) Hypovolemia (1) Inflammation (1) Quenched-FRET (1) Real-time PCR (1) Red blood cells (1) Single nucleotide polymorphism (1) Swine (1) Transfusion (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2018 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model BJMBR Biagini,S.; Dale,C.S.; Real,J.M.; Moreira,E.S.; Carvalho,C.R.R.; Schettino,G.P.P.; Wendel,S.; Azevedo,L.C.P.. The pathophysiological mechanisms associated with the effects of red blood cell (RBC) transfusion on cardiopulmonary function and inflammation are unclear. We developed an experimental model of homologous 14-days stored RBC transfusion in hypovolemic swine to evaluate the short-term effects of transfusion on cardiopulmonary system and inflammation. Sixteen healthy male anesthetized swine (68±3.3 kg) were submitted to controlled hemorrhage (25% of blood volume). Two units of non-filtered RBC from each animal were stored under blood bank conditions for 14 days. After 30 min of hypovolemia, the control group (n=8) received an infusion of lactated Ringer's solution (three times the removed volume). The transfusion group (n=8) received two units of homologous... Tipo: Info:eu-repo/semantics/article Palavras-chave: Swine; Transfusion; Inflammation; Red blood cells; Hypovolemia; Hemorrhage. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100604 Simultaneous detection of the C282Y, H63D and S65C mutations in the hemochromatosis gene using quenched-FRET real-time PCR BJMBR Moysés,C.B.; Moreira,E.S.; Asprino,P.F.; Guimarães,G.S.; Alberto,F.L.. Hereditary hemochromatosis (HH) is a common autosomal disorder of iron metabolism mainly affecting Caucasian populations. Three recurrent disease-associated mutations have been detected in the hemochromatosis gene (HFE): C282Y, H63D, and S65C. Although HH phenotype has been associated with all three mutations, C282Y is considered the most relevant mutation responsible for hemochromatosis. Clinical complications of HH include cirrhosis of the liver, congestive cardiac failure and cardiac arrhythmias, endocrine pancreatic disease, which can be prevented by early diagnosis and treatment. Therefore, a reliable genotyping method is required for presymptomatic diagnosis. We describe the simultaneous detection of the C282Y, H63D and S65C mutations in the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Hemochromatosis; Single nucleotide polymorphism; Quenched-FRET; Real-time PCR. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000001 Registros recuperados: 2 Primeira ... 1 ... Última

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