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| Farias,Carine Coneglian de; Bonifácio,Kamila Landucci; Matsumoto,Andressa Keiko; Higachi,Luciana; Casagrande,Rúbia; Moreira,Estefânia Gastaldello; Barbosa,Décio Sabbatini. |
| Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Furthermore, oxidative stress plays a role in PD, causing or contributing to the neurodegenerative process. Currently PD has only symptomatic treatment and still nothing can be done to stop the degenerative process of the disease. This study aimed to comparatively evaluate the antioxidant capacity of pramipexole, selegeline and amantadine in different in vitrostudies and to offer possible explanations on the molecular antioxidant mechanisms of these drugs. In vitro, the antioxidant capacity of the drugs was assessed by the ability of antiparkinsonian drugs to decrease or scavenge ROS in the neutrophil respiratory burst,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson´s disease; Oxidative stress; Antiparkinsonian drugs/in vitrostudies; Antioxidants. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400819 |
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| Boll,Karine Maria; Bortolasci,Chiara Cristina; Zaminelli,Tiago; Veríssimo,Luiz Fernando; Bacchi,André Demambre; Higachi,Luciana; Barbosa,Décio Sabbatini; Moreira,Estefânia Gastaldello. |
| Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Phytomedicines/evaluation; Passiflora incarnata/use in pregnancy; Passiflora incarnata/use in lactation; Passiflora incarnata/reproductive toxicity/experimental study; Pregnancy/use of phytomedicines; Lactation/use of phytomedicines; Oxidative stress. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353 |
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