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	Provedor de dados OAK (1) Autor Fujikawa, Ryu (1) Ishii, Toshiaki (1) Mori, Kaori (1) Uto, Tomoka (1) 石井, 利明 (1) Palavra-chave Anchorage-independent growth (1) Bovine lactoferrin (1) Cell adhesion (1) Cell growth (1) Cell suspension (1) Cell viability (1) Dominant-negative mutant (1) Integrin (1) Integrin-linked kinase (1) P38 MAPK (1) PC12 cell (1) Mais... Ano 2009 (1) País Japan (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells OAK Ishii, Toshiaki; Uto, Tomoka; Mori, Kaori; Fujikawa, Ryu; 石井, 利明. Aims: Bovine lactoferrin (bLf) causes anchorage-independent cell growth in PC12 cells. The present study investigated the mechanisms involved in bLf-induced anchorage-independent cell growth and survival in PC12 cells. Main methods: The number of adherent cells and suspended cells was estimated separately by using a methyl thiazol tetrazolium (MTT) assay, and the sum of both optical density (O.D.) (570 nm) values was used as a measure of the total number of cells. Key findings: Integrin-linked kinase (ILK) plays an important role in integrin and growth factor signaling pathways. Stable transfection of PC12 cells with a dominant negative kinase-deficient mutant of ILK (DN-ILK) inhibited bLf-induced anchorage-independent cell growth. The ILK activity in the... Palavras-chave: Bovine lactoferrin; PC12 cell; Integrin-linked kinase; Integrin; P38 MAPK; Cell suspension; Cell adhesion; Cell growth; Cell viability; Dominant-negative mutant; Anchorage-independent growth. Ano: 2009 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2675 Registros recuperados: 1 Primeira ... 1 ... Última

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