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	Provedor de dados Genet. Mol. Biol. (2) Autor Mori,Naoki (2) Asakura,Nobuaki (1) Motoji,Toshiko (1) Nakamura,Chiharu (1) Ohtsuka,Ichiro (1) Shiseki,Masayuki (1) Tada,Makiko (1) Wang,Yanhua (1) Yoshida,Shinya (1) Yoshinaga,Kentaro (1) Mais... Palavra-chave Acute myeloid leukemia (1) Aegilops (1) Copy number variation (1) JAK2 gene (1) Lymphoid malignancies (1) Mutator-like transposase (1) Sequence diversity (1) Signal transduction (1) Triticum (1) V617F mutation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Infrequent V617F mutation of the JAK2 gene in myeloid leukemia and its absence in lymphoid malignancies in Japan Genet. Mol. Biol. Mori,Naoki; Yoshinaga,Kentaro; Tada,Makiko; Wang,Yanhua; Shiseki,Masayuki; Motoji,Toshiko. A unique mutation of the JAK2 gene, V617F, has recently been identified in polycythemia vera, essential thrombocythemia and myeloid metaplasia with myelofibrosis. To determine the relevance of this mutation in other types of hematological neoplasms in Japan, we performed allele-specific polymerase chain reaction analysis on the JAK2 gene. The V617F mutation was detected in one out of 130 myeloid neoplasms, but in none of 114 lymphoid malignancies and four biphenotypic acute leukemias. Although a favorable chromosomal alteration t(8;21)(q22;q22) was observed in one acute myeloid leukemia (AML) patient with the mutation, two courses of chemotherapy resulted in induction failure and short survival. Sequencing of JAK2 cDNA revealed expression of the mutant... Tipo: Info:eu-repo/semantics/article Palavras-chave: JAK2 gene; V617F mutation; Signal transduction; Acute myeloid leukemia; Lymphoid malignancies. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300006 Sequence diversity and copy number variation of Mutator-like transposases in wheat Genet. Mol. Biol. Asakura,Nobuaki; Yoshida,Shinya; Mori,Naoki; Ohtsuka,Ichiro; Nakamura,Chiharu. Partial transposase-coding sequences of Mutator-like elements (MULEs) were isolated from a wild einkorn wheat, Triticum urartu, by degenerate PCR. The isolated sequences were classified into a MuDR or Class I clade and divided into two distinct subclasses (subclass I and subclass II). The average pair-wise identity between members of both subclasses was 58.8% at the nucleotide sequence level. Sequence diversity of subclass I was larger than that of subclass II. DNA gel blot analysis showed that subclass I was present as low copy number elements in the genomes of all Triticum and Aegilops accessions surveyed, while subclass II was present as high copy number elements. These two subclasses seemed uncapable of recognizing each other for transposition. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mutator-like transposase; Sequence diversity; Copy number variation; Triticum; Aegilops. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300022 Registros recuperados: 2 Primeira ... 1 ... Última

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