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Are the current chronic allograft nephropathy grading systems sufficient to predict renal allograft survival? 56
Moscoso-Solorzano,G.T.; Mastroianni-Kirsztajn,G.; Ozaki,K.S.; Araujo,S.; Franco,M.F.; Pacheco-Silva,A.; Camara,N.O.S..
A major problem in renal transplantation is identifying a grading system that can predict long-term graft survival. The present study determined the extent to which the two existing grading systems (Banff 97 and chronic allograft damage index, CADI) correlate with each other and with graft loss. A total of 161 transplant patient biopsies with chronic allograft nephropathy (CAN) were studied. The samples were coded and evaluated blindly by two pathologists using the two grading systems. Logistic regression analyses were used to evaluate the best predictor index for renal allograft loss. Patients with higher Banff 97 and CADI scores had higher rates of graft loss. Moreover, these measures also correlated with worse renal function and higher proteinuria...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Renin angiotensin-converting enzyme inhibitor; Chronic allograft damage index; Banff 97; Renal allograft survival; Kidney transplantation.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000011
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Synergistic effect of mycophenolate mofetil and angiotensin-converting enzyme inhibitor in patients with chronic allograft nephropathy 56
Moscoso-Solorzano,G.T.; Mastroianni-Kirsztajn,G.; Ozaki,K.S.; Franco,M.F.; Pacheco-Silva,A.; Câmara,N.O.S..
Experimental data and few clinical non-randomized studies have shown that inhibition of the renin-angiotensin system by angiotensin-converting enzyme (ACE) associated or not with the use of mycophenolate mofetil (MMF) could delay or even halt the progression of chronic allograft nephropathy (CAN). In this retrospective historical study, we investigated whether ACE inhibition (ACEI) associated or not with the use of MMF has the same effect in humans as in experimental studies and what factors are associated with a clinical response. A total of 160 transplant patients with biopsy-proven CAN were enrolled. Eighty-one of them were on ACE therapy (G1) and 80 on ACEI_free therapy (G2). Patients were further stratified for the use of MMF. G1 patients showed a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Renin-angiotensin system; Mycophenolate mofetil; Renal allograft survival; Kidney transplantation.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000500008
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