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The carcinogenic potential of cadmium in the palatal and gingival epithelium of rats: a morphologic and morphometric analysis Braz. J. Vet. Res. Anim. Sci.
Motta,Ana Carolina Fragoso; Migliari,Dante Antonio; Gioso,Marco Antonio; Komesu,Marilena Chinali; Sala,Miguel Angel; Lopes,Ruberval Armando.
Cadmium (Cd) is a heavy metal that exerts a variety of toxic effects, chronic and acute, in exposed organisms. The aim of this study was to investigate the carcinogenic potential of Cd in the palatal and gingival epithelium of Wistar rats. Two groups of animals were studied: group 1 consisted of 5 rats exposed to cadmium chloride (CdCl2) in drinking water (300 mg/L) for 6 months; group 2 also consisted of 5 rats placed in the same conditions as those of group 1, but kept free of Cd for 6 additional months. Two other groups (C1 and C2) with the same number of animals, but not exposed to CdCl2, were used as a control for groups 1 and 2, respectively. All animals were weighed before and after the experimental period. After animals being killed, tissues of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cadmium chloride; Ooral cancer; Carcinogenesis; Rat.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962004000300006
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