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	Provedor de dados BJPS (2) Autor Andreazza,Itamar Francisco (2) Murakami,Fábio Seigi (2) Goebel,Karin (1) Sato,Mayumi Elisa Otsuka (1) Sato,Mayumi Eliza Otsuka (1) Souza,Dayse Fernanda de (1) Tondo Filho,Volnei Jose (1) Mais... Palavra-chave Diclofenac diethylamine/gel (1) Enteric release mini-tablets/development (1) Enteric release mini-tablets/evaluation (1) Generic semisolid drug products (1) In vitro release test (1) Multiparticulate system/modified release (1) Omeprazole/dissolution (1) Synthetic membranes (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole BJPS Tondo Filho,Volnei Jose; Andreazza,Itamar Francisco; Sato,Mayumi Elisa Otsuka; Murakami,Fábio Seigi. The main aim of this study was to develop a multiparticulate system containing mini-tablets of omeprazole formulated with an enteric polymer with pH-dependent solubility. Pre-formulation studies showed good flow and compaction capacity, leading to the production ofhigh quality mini-tablets. The mini-tablets were coated in a fluidized bed with hydroxypropylmethylcellulose /Eudragit(r) L30D55 and packed into hard gelatin capsules. The dissolution profile showed gastro-resistance and zero-order kinetics. The dissolution profile for the formulation containing lactose as the diluent and coated with 12% (tablet weight gain) of polymer was similar to that ofthe reference drug. Tipo: Info:eu-repo/semantics/article Palavras-chave: Multiparticulate system/modified release; Enteric release mini-tablets/development; Enteric release mini-tablets/evaluation; Omeprazole/dissolution. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300505 In vitro release of diclofenac diethylamine from gels: evaluation of generic semisolid drug products in Brazil BJPS Goebel,Karin; Sato,Mayumi Eliza Otsuka; Souza,Dayse Fernanda de; Murakami,Fábio Seigi; Andreazza,Itamar Francisco. In order for the pharmacological action of a topical dermal drug product to occur, the drug must first be released from the vehicle to be available to penetrate the skin layers and reach the site of action. Drug release is mainly dependent on the characteristics of the formulation. Currently, to register a generic or a similar drug product in Brazil performance testing of topical drug products for local action is not required. In this context, this aim of this study was to evaluate the in vitro release of commercial diclofenac diethylamine gel products available on the Brazilian pharmaceutical market, using the vertical diffusion cell method. Factors which may influence the test, such as the type of membrane used, and the effect of the formulation... Tipo: Info:eu-repo/semantics/article Palavras-chave: In vitro release test; Diclofenac diethylamine/gel; Synthetic membranes; Generic semisolid drug products. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200003 Registros recuperados: 2 Primeira ... 1 ... Última

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